Cell shape determines gene expression: cardiomyocyte morphotypic transcriptomes
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte Marker Expression in Mouse Embryonic Fibroblasts by Cell-Free Cardiomyocyte Extract and Epigenetic Manipulation
Background: The regenerative capacity of the mammalian heart is quite limited. Recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. We investigated whether fibroblasts could transdifferentiate into myocardium.Methods: Mouse embryonic fibroblasts were treated with Trichostatin A (TSA) and 5-Aza-2-Deoxycytidine (5-aza-dC). The treated cells were permeabilized w...
متن کاملPervasive concerted evolution in gene expression shapes cell type transcriptomes
Transcriptomic data yields valuable insights into cell type, tissue, and organ evolution. However, interpreting this data requires understanding how transcriptomes evolve. A particularly difficult problem is that cell type transcriptomes may not evolve independently. Here we present a statistical model to estimate the level of concerted transcriptome evolution and apply it to published and new ...
متن کاملBacillus subtilis Noise in Gene Expression Determines Cell Fate
www.sciencemag.org (this information is current as of August 17, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/317/5837/526 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1140818/DC1 can be found at: ...
متن کاملcardiomyocyte marker expression in mouse embryonic fibroblasts by cell-free cardiomyocyte extract and epigenetic manipulation
background: the regenerative capacity of the mammalian heart is quite limited. recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. we investigated whether fibroblasts could transdifferentiate into myocardium. methods: mouse embryonic fibroblasts were treated with trichostatin a (tsa) and 5-aza-2-deoxycytidine (5-aza-dc). the treated cells were permeabilized ...
متن کاملNoise in gene expression determines cell fate in Bacillus subtilis.
Random cell-to-cell variations in gene expression within an isogenic population can lead to transitions between alternative states of gene expression. Little is known about how these variations (noise) in natural systems affect such transitions. In Bacillus subtilis, noise in ComK, the protein that regulates competence for DNA uptake, is thought to cause cells to transition to the competent sta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Basic Research in Cardiology
سال: 2019
ISSN: 0300-8428,1435-1803
DOI: 10.1007/s00395-019-0765-7